A multivariate analysis was additionally conducted to identify factors predictive of OS and DFS (Table 3), revealing that elevated HANR expression independently predicted reduced OS (HR = 2.501, 95% CI: 1.956–4.108, P = .023) and DFS (HR = 2.314, 95% CI: 1.713–3.956, P = .012) in CRC patients. This evidence concerns the gene RPL13AP20 and colorectal carcinoma.