Other studies buttress the view that increased FoxO signalling and the activation of the transcription factors nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB), MuRF1, and muscle atrophy F‐box (MAFbx) in skeletal muscle play major roles during cachexia onset and progression.10 MuRF1 and MAFbx are essentially involved in muscle atrophy development. The gene discussed is TRIM63; the disease is Cachexia.