Furthermore, we observed that bioinformatically predicted FH-associated variants were associated with comparable LDL-C levels and similar risk of premature CVD compared with variants with likely pathogenic or pathogenic annotations in ClinVar.37,38 Of note, we found that many individuals with variants annotated as pathogenic for FH did not display severe hypercholesterolemia. The gene discussed is FH; the disease is familial hypercholesterolemia.