Certain levels of plasma or serum LEP can exert other physiologicaleffects, such as enhancing endothelial cell oxidative stress, stimulating growth ofvascular smooth muscle cells, inducing arterial vascular wall injury, stimulatingformation of reactive oxygen species, and stimulating therenin-angiotensin-aldosterone system17,18 All of these effects may influence development of CAD. Here, LEP is linked to coronary artery disorder.