Withadvances in studies on molecular biology, several bioactive molecules have beenfound to play an important role in remodeling the posterior scleral pole in myopia.Studies have confirmed that three subtypes of transforming growth factor-β(TGF-β1, TGF-β2, and TGF-β3) all play an important role inscleral remodeling. The gene discussed is TGFB3; the disease is myopia.