In those studies, Yu et al. (12) found that pravastatin significantly decreases (P<0.05) the progressive elevation of plasma leptin and, subsequently, significantly decreases (P<0.05) the body weight and food intake in a model of rats spontaneously developing type II diabetes mellitus, the Otsuka Long-Evans Tokushima Fatty rats. The gene discussed is LEP; the disease is type 2 diabetes mellitus.