Like Itgax, Cst7 has been shown to be a marker for activated microglia and upregulated in AD pathology (Keren-Shaul et al., 2017, Ofengeim et al., 2017); of note, Cst7 was previously reported to be the top upregulated gene in cortex samples from 12-month-old APP NL-G-F knockin mice (Castillo et al., 2017). This evidence concerns the gene APP and Alzheimer disease.