APOE and Alzheimer disease: In the turquoise module the four genes with the highest intramodular connectivity (i.e., those with most connections to other genes) were Cd63, Msn, Npc2, and Tnfrsf1a (Table S9), with other highly interconnected transcripts including several genes identified as having a role in LOAD from GWAS (e.g., Abca1, Clu, and Apoe) in addition to genes previously implicated in AD pathology (e.g., Itgax, Clec7a, and Cd68).