Other top-ranked genes progressively altered in rTg4510 mice were notably enriched for microglial markers previously shown to be upregulated in AD (Hopperton et al., 2018, Keren-Shaul et al., 2017), including Cd68 (Figure 3B; LRT statistic = 103.77, FDR = 2.26E−18), Itgax (or Cd11c) (Figure 3C; LRT statistic = 86.85, FDR = 6.54E−15), and Clec7a (Figure 3D; LRT statistic = 83.20, FDR = 2.97E−14). This evidence concerns the gene ITGAX and Alzheimer disease.