HSPA5 and amyloidosis: Although the transcriptional changes associated with the rTg4510 and J20 genotypes are generally distinct—there is no robust correlation of effect sizes (TG versus WT) between models for differentially expressed transcripts identified in either the rTg4510 (Pearson correlation, r = 0.15, p = 0.063; Figure S5A) or J20 (r = 0.66, p = 0.23; Figure S5B) models—it is noteworthy that Hspa5 is significantly downregulated (FDR < 0.05) in the entorhinal cortex in the same direction in both models, implicating a role for ER stress in both tau and amyloid pathology.