GCK and cancer: Metabolic reprogramming was an adaptation to the local environment, which was first identified in tumour and recognized as a hallmark of cancer.17 It was reported that HFD induced the alteration of nutrients metabolism, which is also regarded as metabolic reprogramming.18 Our results showed that the mRNA expressions of GCK and PFK‐1 involved in glycolysis were suppressed (Figure 1B,C) whereas G6Pase and PEPCK modulating gluconeogenesis were enhanced in the liver of mice during HFD feeding (Figure 1D,E).