The previous study confirmed that PANK1 locus was activated by P53 and the coregulation of PANK1 and its intronic miRNA‐107 were characterized.10 As inhibition of P53 attenuates steatosis and liver injury in a mouse model of non‐alcoholic fatty liver disease induced by HFD,11 we assume that HFD may promote the co‐transcriptional activation of PANK1 and miRNA‐107 by activating P53, which leads to the metabolic reprogramming and IR. This evidence concerns the gene TP53 and steatosis.