PANK1 and diabetes mellitus: The PANK activity in the liver varied in conjunction with CoA levels, and increased in diabetes or treatment with hypolipidemic agents.30 Reduction in hepatic CoA because of PANK1 deficiency or chemical inhibition of PANK isoforms results in reduced FAO and hypoglycaemia, demonstrating that modulation of CoA has a direct impact on glucose production.31 In particular, PANK1‐deficient mice are unable to convert pyruvate, oxaloacetate or glycerol into glucose.4 Our results showed that HFD increased the expression of PANK1 in the liver.