Our data in AML12 cells indicated that IR induced by PA was independent to the expression of PANK1, which is consistent with the previous data in vivo.4 Genomic context of PANK1 showed that miR‐107 located within intron of PANK1 gene and was co‐transcribed as reported in tumour cells and validated in AML12 cells.10 MiR‐107 was reported to inhibit the translation of Cav1, which participated in the formation of caveolae and assisted IRβ anchoring on the plasma membrane.8 Our results showed that PA induced IR and inhibited the expression of Cav1 and IRβ in a dose‐dependent manner. This evidence concerns the gene CAV1 and neoplasm.