SMAD3 and non-small cell lung carcinoma: Meanwhile, the expression level of SUMO1P3 in metastatic lymph node specimens was up‐regulated in comparison with primary NSCLC tissue specimens.26 They also found SUMO1P3 promoted NSCLC cell migration and invasion by repressing miR‐136,26 which directly targeted Smad2 and Smad3 to inhibit epithelial‐mesenchymal transition (EMT) process in lung cancer cells.27