Thus, a massive T-cell mediated inflammation in the presence of circulating anti-MOG antibodies results in an ADEM-like inflammatory disease, with perivenous (sometimes confluent) demyelination, while in the presence of a mild T-cell mediated inflammation with high titers of circulating antibodies focal (MS-like) demyelinating plaques are induced [41]. Here, MOG is linked to acute disseminated encephalomyelitis.