Recent phase I clinical data from our group demonstrated that a FRα peptide vaccine elicited a durable (at least 12 months) T-cell response to the FRα peptides in 90% of patients, including both breast and ovarian cancer.24 Therefore, further augmenting immune responses to patients with TNBC may be of substantial therapeutic relevance, and a randomized phase II trial (including correlative studies of FRα expression with high performance IHC assay) is ongoing to test a FRα vaccine in patients with high risk, resected TNBC (NCT03012100). Here, FOLR1 is linked to ovarian cancer.