AGR2 (0.39-fold), FAM3D (0.15-fold), PIP (0.46-fold), DSE (0.33-fold), and TMC (0.46-fold) decreased, and all of them were significantly different between groups, which were associated with the phenotype of CRSwNP, while ST6GAL1 (0.77-fold), COTL1 (1.19-fold), PHLDA1 (0.58-fold), and MLPH (0.96-fold) were not significantly different between groups. The gene discussed is FAM3D; the disease is chronic rhinosinusitis with nasal polyps.