EIF2A and neoplasm: Proteins that were congruent in both PDX isolates for regulating tumor cell killing by the drug combination were: [BAX, BAK, BAD; MCL-1, BCL-XL] that could be considered as a mitochondrial apoptosis regulatory pathway; [ATM, AMPK, ULK-1, ATG5, Beclin1, Cathepsin B] that could considered as an autophagy/lysosomal pathway; [CD95, c-FLIP-s] as a death receptor pathway feeding into the apoptosis pathway; and enhanced [PERK, eIF2α] ER stress signaling that promotes cell survival (Figures 7A,B).