FOXM1 and esophageal squamous cell carcinoma: To determine whether knockdown of FOXM1 attenuates the oncogene function of MELK in ESCC cells, two different shRNA oligonucleotides targeting the coding sequence of human FOXM1 (shFOXM1#1 and shFOXM1#2) were stably transduced into MELK-overexpressing KYSE70 and EC109 cells.