SOST and osteoporosis: Although ROMO, a humanized monoclonal antibody against sclerostin, was recently approved for osteoporosis treatment, it carries a black box warning against increased risk of cardiovascular events.42 Considering ROMO likely increases signaling by multiple Wnt proteins which may have nonoverlapping functions, targeting specific Wnt ligands such as Wnt7b may afford an opportunity to achieve the bone anabolic function while avoiding the unwanted side effects.