In pancreatic cancer cells, miR-142-5p has been found to target Ras-related protein Rap-1A (RAP1A) to downregulate p-ERK1/2 and phosphate p38 mitogen-activated protein kinases (p-p38) and control cell proliferation and apoptosis [33]. This evidence concerns the gene MAPK3 and familial pancreatic carcinoma.