EPO and perinatal asphyxia: A phase II, multicenter, double-blinded controlled trial in the Unites States (NEATO) in term newborns with moderate to severe HIE found that multiple doses of erythropoietin (1000 U/kg) given intravenously for 7 days was associated with reduced severity of brain injury on neonatal MRI, specifically in the subcortical region, and improved motor function at 1 year among infants undergoing therapeutic hypothermia70.