The CT genotype of MACC1 rs975263 was suggested to be associated with a reduced survival for younger colon cancer patients in early stages 23, and TT genotype of SNP rs1990172 in gene MACC1 was associated with worse disease-free survival (DFS) in patients of resectable colorectal cancer (CRC) and was found to exhibit higher frequency in patients with T3/T4 staging 26. The gene discussed is MACC1; the disease is colorectal cancer.