The highest distribution frequencies in the controls and patients with HCC of MACC1 genetic polymorphisms rs1990172, rs975263, rs3095007, rs4721888, and rs3735615 were homozygous for CC, homozygous for AA, homozygous for CC, homozygous for GG, and homozygous for GG, respectively. This evidence concerns the gene MACC1 and hepatocellular carcinoma.