To clarify the role of MACC1 genetic polymorphisms in HCC status in relation to clinical stage, tumor size, lymph node metastasis, distant metastasis, vascular invasion, Child-Pugh grade, HBsAg, anti-HCV, and liver cirrhosis, the distribution frequency of clinical status and MACC1 genotype frequency in the patients with HCC was estimated. This evidence concerns the gene MACC1 and neoplasm.