In the current study, we selected five MACC1 SNPs rs1990172, rs975263 (exon 5), rs3095007, rs4721888 (exon 4), rs3725615 (exon 7), and try to elucidate their correlations to Taiwanese HCC patients and cancer prognosis. The gene discussed is MACC1; the disease is hepatocellular carcinoma.