To further analyze and elucidate the relationship between the level of clinical pathological markers and progress of clinical status in patients with HCC, we analyzed the levels of common clinical pathological markers of HCC including α-fetoprotein (AFP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) associated with MACC1 genotypic frequencies. Here, MACC1 is linked to hepatocellular carcinoma.