MACC1 and cirrhosis of liver: Compared with this result, our study have found that the MACC1 rs4721888 is associated with higher risk of vascular invasion in HCC patients among drinkers (Table 4), and most of the HCC patients involved in our study have liver cirrhosis (82.3%; Table 1) and classified as Child-Pugh grade A (79.9%; Table 1).