In contrast, a significant association was found in alcohol drinking between the HCC patients and controls (p < 0.001; Table 1), and we found that carriers of MACC1 rs4721888 "GG" and "GC+CC" genotype in HCC patients among drinkers have higher risk to develop vascular invasion ([OR] = 3.780, p = 0.009) compared with the MACC1 rs4721888 "GG" genotypic variant (Table 4). Here, MACC1 is linked to hepatocellular carcinoma.