Leung et al. discovered that binding αVβ3 integrin could activate FAK/CREB signaling pathway and increase the expression of TNNC1 which would lead to poor prognosis 31; Wu et al. claimed that MFAP5 promote EMT program in breast cancer by activated TGF-β/Notch pathway 32. The gene discussed is CREB1; the disease is breast carcinoma.