Furthermore, LGALS1 knockdown resulted in a sharp decline in the Bcl-2 protein expression in both SiHa and C33A cell lines accompanied with no variation in the level of Bax protein, suggesting that LGALS1 influenced the apoptosis of cervical cancer cells mainly through regulating the expression of Bcl-2 but not Bax. The gene discussed is LGALS1; the disease is cervical carcinoma.