At present, a practical and feasible method is to combine several diffirent models, such as pancreatic cancer model with type 2 diabetes induced by injection of STZ into KIC mice with high-fat diet, panreatitis-pancreatic cancer model established by bombesin injecting into KIC mice, and KIC mice intervened with smoking, high-fat or high-chelesterol diet. The gene discussed is GRP; the disease is familial pancreatic carcinoma.