In RCC, disturbance of AS of genes such as EZH2, PKM and FGFR2 have been observed by previous studies and isoform switches of these genes played active roles in the proliferation, growth and invasion of RCC 8, 14, 15, which demonstrated the immense value of AS in developing novel anti-cancer strategies for RCC. Here, FGFR2 is linked to renal cell carcinoma.