ALK and non-small cell lung carcinoma: After the first drug target, the epidermal receptor factor EGFR, was discovered in NSCLC 4, Soda et al. 5 found the echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase (EML4-ALK) fusion gene, which can induce the occurrence of lung cancer, in lung adenocarcinoma patients in 2007.