In the same way, our data show that neuroblastoma cells deficient in FL BARD1 tend to accumulate γH2AX phosphorylation spontaneously or upon DNA insults suggesting higher levels of FL BARD1 expression protect neuroblastoma cells from DNA damages accumulation while lower levels of FL BARD1 make cells prone to carcinogenesis by accumulating more mutations. This evidence concerns the gene BARD1 and neuroblastoma.