It has been reported that the tumor suppressor gene PTEN is down-regulated in a variety of cancers, including breast cancer 32, prostate cancer 32 and EC 33, etc. PTEN deficiency accelerates tumuor progression and invasiveness 34, promotes macrophage infiltration 35, and plays a significant role in the pathogenesis of carcinogenesis 36. The gene discussed is PTEN; the disease is cancer.