recent researches display increased glucose uptake and aerobic glycolysis of KRAS-induced LC, Enhanced aerobic glycolysis lead to LC cells extracellular matrix microenvironment changes, and the microenvironment can facilitate the occurrence and development of KRAS-induced LC 39-41.Similar results were found in EGFR-driven LC, and tissue environment is an important determinant of tumor metabolic phenotypes 42. This evidence concerns the gene KRAS and laryngotracheoesophageal cleft.