However, high grade gliomas with good prognosis factors, such as having 1p/19q codeletion, could appropriately use conservative management without radiation in some cases, rather than the typical treatment consisted of varying combinations of surgery, chemotherapy, and radiotherapy, which was recently, to some extent, confirmed by Sorge C et al. 59, for they found a WHO III anaplastic oligodendroglioma with IDH wildtype and 1p/19q codeletion in a children only underwent a near total resection and had a complete, durable response to temozolomide alone. Here, IDH2 is linked to central nervous system cancer.