For the molecular status of TERT and MGMT promoter, the patients with TERTp wild type (especially in WHO IV/GBM) and MGMTp methylated had a better survival (Median OS of TERTp wild type=33 months, Median OS of TERTp mutated=22 months; p<0.001, Median OS of MGMTp methylated=35 months, Median OS of MGMTp methylated=23 months; p=0.004). The gene discussed is TERT; the disease is glioblastoma.