In vivo analysis showed that the tumor volumes of in the MG-63-shRNA-RNF187 or HOS group were smaller compared to their controls (p<0.05, Figure 3 D), and the incidences of lung metastasis were 40% and 20% in the MG-63-shRNA-RNF187 and HOS groups compared to 100% in the control groups, respectively (Figure 3E). This evidence concerns the gene RNF187 and neoplasm.