Ring finger protein 187 (RNF187), a RING domain-containing ubiquitin E3 ligase, was lately verified to overexpressed in hepatocellular carcinoma and non-small cell lung carcinoma and advanced tumor development by inducing tumor cell epithelial-mesenchymal transition (EMT) 6, 7. The gene discussed is RNF187; the disease is non-small cell lung carcinoma.