Other studies have shown that expression of GSK3β can inhibit the expression of miR-183 through the β-Catenin/TCF/LEF-1 pathway in human gastric cancer cells, while β-Catenin/TCF/LEF-1 binds to the promoter of miR-183 and thereby activates the transcription of miR-183 8. This evidence concerns the gene LEF1 and gastric cancer.