Compared with control group, the % area of Iba-1 positive expression of hippocampus CA1 (Dss vs Con, 3.42 ± 0.41 vs 2.92 ± 0.23, P > 0.05), CA3 (2.02 ± 0.35 vs 2.97 ± 0.37, P > 0.05) and DG (3.33 ± 0.39 vs 3.79 ± 0.67, P > 0.05) showed no significant difference after DSS-induced colitis (Figure 4). The gene discussed is AIF1; the disease is colitis.