The variant allele PTPN22R619W is also defective in regulating lymphopenia-induced proliferation and CD8 T cells expressing this variant also have increased production of inflammatory cytokines indicating that this mutation could pose a risk factor for the development of secondary autoimmunity in man as a sequela to Ab-mediated lymphodepletion that failed to spare Tregs. Here, CD8A is linked to Autoimmunity.