In some cases, other variants in the same molecule have even been associated with other PIDs, such as chronic mucocutaneous candidiasis for IL-17F, recurrent pyogenic infections for IRAK4, and autoinflammatory fever syndromes for TNFAIP3, TNFRSF1A, and PLCG2, although mostly in patients homozygous for the given variant. This evidence concerns the gene TNFRSF1A and Chronic mucocutaneous candidosis.