PLCG2 and pneumococcal meningitis: Finally, in P18, a 40-year-old male with idiopathic thrombocytopenia in childhood and severe pneumococcal meningitis at the age of 34 years, two variants in PLCG2 and TNFRSF1A were identified (Tables 2, 3), The specific variant, PLCG2 p.R956C, is rare and potentially harmful with a high CADD score of 35 but not previously described in association with disease (Tables 2, 3), and selection against missense variants seems to be low (o/e = 0.92).