The release of pro-inflammatory cytokines usually causes excessive inflammatory response, mainly including interleukin IL-1β, IL-6, tumor necrosis factor (TNF-α) (Sun et al., 2018), and other members of the IL-1 gene family, for example, IL-18, IL-33 (Han et al., 2017; Yaneisi et al., 2019), etc. The Pulmonary inflammation and injury maybe caused by inflammasome activation, which can be resulted from viral infection of RSV infection (Yoo et al., 2013; Triantafilou and Triantafilou, 2014; Rivera-Toledo et al., 2017; Segovia et al., 2017). This evidence concerns the gene IL18 and viral infectious disease.