In fact, albumin in tear film may serve as a double-edged sword, being detrimental to the ocular bioavailability of topically administered medications, but also beneficial for symptomatic relief of dry eye (Shimmura et al., 2003; Seki et al., 2015), corneal wound healing (Shimmura et al., 2003), and anti-oxidative and anti-inflammatory activities (Merlot et al., 2014). Here, ALB is linked to Keratoconjunctivitis sicca.