UGT2B17 was shown to stimulate cancer cell proliferation, invasion and progression to castration-resistant PCa in a mouse xenograft model after prolonged androgen deprivation.44 In this study, the action of UGT2B17 was mediated by the activation of the c-Src kinase, enhancing ligand-independent AR signalling.44 However, in the latter study, the correlation between UGT2B17 tumour expression and clinical outcomes was not evaluated in men with PCa. This evidence concerns the gene UGT2B17 and cancer.