A proteomic study further supports the concept that increased UGT2B expression is associated with PCa aggressiveness.17 Previous gene expression studies have also established that UGT2B17 mRNA expression is upregulated in metastasis,21,42,43 implying that UGT2B17 expression is enhanced in aggressive cancer cells. This evidence concerns the gene UGT2B17 and posterior cortical atrophy.