UGT2B17, along with UGT2B15 and UGT2B28, is a major enzyme involved in steroid inactivation in both normal and prostatic cancer cells (Fig. 1).18–20 UGT2B17 shares 94% amino acid sequence identity with UGT2B1518 and 76% with UGT2B28.20 It was previously documented that UGT2B17 mRNA expression is associated with PCa disease stages, being overexpressed in castration-resistant metastasis.21 More recently, the complexity of the UGT2B17 transcriptome was exposed with at least ten alternative mRNA isoforms,22 but it remains unclear which transcripts are linked to disease stages. Here, UGT2B28 is linked to prostate carcinoma.