In agreement with our findings observed at the protein level, UGT2B17 mRNA expression was also increased in metastasis compared with primary tumours in three independent data sets (Supplementary Fig. 3).29–31 A multivariable analysis of the Taylor data set (n = 131)30 further suggested that primary PCa patients with elevated UGT2B17 mRNA level had superior BCR rates (HR = 2.4; 95% CI: 1.00–5.67; P = 0.051). This evidence concerns the gene BCR and posterior cortical atrophy.