BCR and posterior cortical atrophy: UGT2B17 is a key enzyme involved in the control of steroid metabolism in normal prostate and PCa cells.18 In our study, we evidenced a differential UGT2B17 protein expression and subcellular distribution in primary PCa compared with normal glands, and the association of cytoplasmic staining with positive nodes at surgery, circulating steroid levels and an independent risk factor of BCR after RP.