Indeed, although we have uncovered a link between circulating steroid levels and survival in CLL patients, UGT2B17 germline deletion or UGT2B17 mRNA expression levels in leukaemic B cells from CLL patients did not affect this relationship.85 This suggests that UGT2B17 might exert pro-leukaemic effects either through the metabolism of other endogenous metabolites and/or independently of its enzymatic activity. This evidence concerns the gene UGT2B17 and B-cell chronic lymphocytic leukemia.