TP53 and Splenomegaly: Rassf10 knockout promotes increased numbers of thymoma (p53−/− [47]), cystic kidneys (p53−/− [48, 49]), lymphoma (Rassf1A−/− [34], p53−/− [32, 50]), and splenomegaly (Rassf1A−/−, p53−/− [51]).