Recently it was shown that treatment with retinoids such as ATRA decreased viability of BCR-ABL Arf−/− and BCR-ABL IKAROS-mutated acute lymphoblastic leukemia in vitro21, however, it is unknown how vitamin A insufficiency might affect growth of or survival from BCR-ABL leukemia in vivo. Here, ABL1 is linked to acute lymphoblastic leukemia.