To further validate the potential of Wee1 inhibition as a chemopreventive therapy, a panel of premalignant cell cultures was treated with Adavosertib, together with a panel of HNSCC and two ovarian tumor cell lines as reference, since ovarian cancer is known to be vulnerable to Wee1 inhibition in clinical studies20,22. Here, WEE1 is linked to head and neck squamous cell carcinoma.