The levels of tumor necrosis factor alpha (TNF-α) protein in the CNS also increased after infection and were higher in WT-infected mice at 2 days postinfection in the brain (P < 0.05 versus Y114A, P < 0.001 versus G32S) and remained high in the spinal cords of Y114A-infected mice at 8 days (P < 0.0001) (Fig. 8C). The gene discussed is TNF; the disease is infection.