An almost identical pattern of brain hypometabolism and small vessel disease colocalizes with reduced white matter integrity in diffusion tensor imaging and correlates with cognitive impairment in the absence of overt brain atrophy in DLB.54, –, 57 Of interest, minimal atrophy was the second most common pattern in DLB.19 Therefore, tau and concomitant pathologies may disconnect key brain networks in minimal atrophy AD, giving the symptoms in the absence of overt brain atrophy. This evidence concerns the gene MAPT and Brain atrophy.