MAPT and Alzheimer disease: This finding is coherent with the possible contribution of TAR DNA-binding protein 43 (TDP-43) pathology, hippocampal-sclerosis, and the microtubule-associated protein tau (MAPT) H1H1 genotype to limbic-predominant AD, 3 factors that are related to atrophy restricted to the medial temporal lobes, older age, and slower disease progression.