Because high concentrations of Aβ, however, induced a decrease of p-Ser422 Tau (Fig. 4B, C and 4E), it is likely that severely advanced AD patients along with high Aβ accumulation exhibit a relatively low level of p-Ser422 Tau along with an increase of p-Ser455 ACL in patients number 2 and 6 (Fig. 7C and sFig. 5C). This evidence concerns the gene MAPT and Alzheimer disease.