G6PC1 and hepatocellular carcinoma: Interestingly, Cho et al. [33] demonstrated lower glucose 6-phosphatase expression in Hepatic adenoma and HCC compared to that in non-tumor tissue in a G6PC-knockout mouse after gene therapy despite a similar copy number for the vector genome, and they suggested that the downregulation of glucocorticoid signaling in tumor tissue inhibits gene therapy expression and tumor abrogation.