The objective of this study was to determine whether immunohistochemical (IHC) expression of LEP, LEPR, ADIPOQ, ADIPOR1, and ADIPOR2 are associated with breast tumor clinicopathological characteristics, namely those that are indicative of aggressive phenotypes among Black and White women newly diagnosed with breast cancer, including poor differentiation (higher tumor grade), larger tumor size, positive lymph node status, unfavorable Ki67 status (Ki67+), ER− status, HER2+ status, and non-luminal HER2-enriched (HER2-E) and triple-negative (TN) subtypes. This evidence concerns the gene ESR1 and neoplasm.