Given that Black women also tend to have higher age-adjusted prevalence rates of obesity (approximately 57% among non-Hispanic Black vs. 40% among non-Hispanic White women [4]), we hypothesize that inter-individual variation in adiposity and adiposity-related biomarkers (namely leptin [LEP], leptin receptor [LEPR], adiponectin [ADIPOQ], adiponectin receptor 1 [ADIPOR1], and adiponectin receptor 2 [ADIPOR2]) within the breast tumor microenvironment might be involved in the observed racial differences in aggressive breast cancer phenotypes between Black and White women. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.