ADIPOQ and neoplasm: Moreover, as ADIPOQ exerts its effects through ADIPOR1 and ADIPOR2, more in-depth analysis of the predictors of ADIPOQ, ADIPOR1, and ADIPOR2 IHC expression in the tumor microenvironment and the impacts of their expression on tumor clinicopathology and subsequent survival outcomes, by adiposity type (e.g., overall adiposity, visceral) as well as by ER status, are critically needed.