In fact, the exogenous administration of low doses of IGF-1 in experimental cirrhosis improved nutritional status and nitrogen balance [140], intestinal absorption [141–144], osteopenia [145, 146], testicular atrophy [147, 148], restored somatostatinergic tone controlling growth hormone (GH) secretion [149] and induced hepato-protective actions in the liver associated with a reduction in oxidative damage and enhancing mitochondrial protection [150–153]. This evidence concerns the gene GH1 and Cirrhosis.