TP53 and Insulin resistance: However there was also negative result showed CXCL7failed to induce M1/2 macrophage chemotaxis, which could be attributable to the different state of the macrophage [46], In vitro experiments further showed that CRP promoted the monocyte migration by stimulating the production of CXCL7 by 3T3-L1 adipocytes, Besides, KEGG analysis also showed the P53 signal pathways activation in adipose tissue, It is reported p53 induces adipose tissue inflammation by promoting the development of insulin resistance.