However there was also negative result showed CXCL7failed to induce M1/2 macrophage chemotaxis, which could be attributable to the different state of the macrophage [46], In vitro experiments further showed that CRP promoted the monocyte migration by stimulating the production of CXCL7 by 3T3-L1 adipocytes, Besides, KEGG analysis also showed the P53 signal pathways activation in adipose tissue, It is reported p53 induces adipose tissue inflammation by promoting the development of insulin resistance. This evidence concerns the gene PPBP and Insulin resistance.