In the subgroup analysis, TNF-α 238G/A locus A showed significant association with higher CAD susceptibility in the subgroup of Europeans: the homozygote model (AA vs. GG) (OR:2.961, 95% CI:1.113–7.9879); the regressive model (AA vs. GA + GG) (OR: 2.985, 95% CI: 1.121–7.946). This evidence concerns the gene TNF and coronary artery disorder.