In the migraine with aura subgroup, only 1 (TNF-α/rs1800629) and 3 (MTHFR/rs1801133, ESR1/rs1801132 and TNF-α/rs1800629) genetic variants was noteworthy in FPRP at the prior probability of 0.05 with a statistical power to detect an OR of 1.2 and 1.5, respectively. The gene discussed is ESR1; the disease is migraine disorder.