Tumor suppressors Krüppel-like factor 4 (KLF4; at 2 h) and p53 (at 24 h) transcript levels were elevated, while those of tumor promoters c-FOS (at 24 h) and telomerase (TERT; at 2 h) were reduced (relative to t = 0), with MET treatment (Fig. 4b). Here, KLF4 is linked to neoplasm.