Recently, commercial fucoidan from U. pinnatifida (average 130 kDa with 21% ± 3% fucose, 20% ± 5% galactose, 2% ± 2% mannose, and 30% ± 3% sulphate) was also shown to induce apoptosis in MG63 osteosarcoma cells characterised by increased roundness of the cells due to accumulation of F-actin at the cortex and increased expression of Annexin V together with chromatin condensation [33]. This evidence concerns the gene ANXA5 and osteosarcoma.